In the particular case of lettuce, different nutrient solution compositions have varying effects on the plant, this, of course, because the particular chemistry of your nutrient solution must be fitted for your plant in order to achieve optimum results. The use of generic solutions to feed your plants will more often than not end with some loss in product quality (dry weight, nutrient content, marketability, etc).
In a peer reviewed study published in 2004, M.S. Karimaei et al  compared different nutrient solutions for lettuce cultivation under hydroponic conditions. Amongst their conclusions, was that the Hoagland solution offers the best conditions for lettuce cultivation amongst the solutions they tested. They also found some important factors such as the electrical conductivity being inversely correlated to dry weight and K concentration. This shows the utmost importance that using the correct and not the “generic” nutrient solution has on your lettuce growing potential.
 Karimaei, M.S., Massiha, S. and Mogaddam, M. 2004. COMPARISON OF TWO NUTRIENT SOLUTIONS’ EFFECT ON GROWTH AND NUTRIENT LEVELS OF LETTUCE (LACTUCA SATIVA L.) CULTIVARS. Acta Hort. (ISHS) 644:69-76